INTRAVASCULAR OSTEOCLASTS

Subacute Inflammatory Arthritis Following Intravascular Coagulation Syndrome

Un nourisson de six mois a ete hospitalise dans le .,ervice de pediatrie du C.H.U. de Logmandolhe-Adham pour: deshydratation, etat septique, acidose metabolique, troubles circulatoires des membres avec gangrene de la main droite.  Le syndrome de la coagulation intra-vasculaire disse­minee (CID) a ete rapidernent confirme par l'etude de la erase sanguine. Soumis a un traitement par: solutes 6le...

Cross-Presentation by Osteoclasts Induces

Osteoclasts; culprits in inflammatory osteolysis

Periarticular osteolysis, a crippling complication of rheumatoid arthritis, is the product of enhanced osteoclast recruitment and activation. The osteoclast, which is a member of the monocyte/macrophage family, is the exclusive bone resorptive cell, and its differentiation and activation are under the aegis of a variety of cytokines. Receptor activator of NF-kappaB ligand (RANKL) and macrophage...

Nano-topography sensing by osteoclasts.

Bone resorption by osteoclasts depends on the assembly of a specialized, actin-rich adhesive 'sealing zone' that delimits the area designed for degradation. In this study, we show that the level of roughness of the underlying adhesive surface has a profound effect on the formation and stability of the sealing zone and the associated F-actin. As our primary model substrate, we use 'smooth' and '...

Osteoclasts: Crucial in Rheumatoid Arthritis

Osteoclasts are a major component of bone metabolism in physiologic condition and in rheumatoid arthritis (RA). RA is a chronic, autoimmune, inflammatory disease primarily affecting the joints. Joint inflammation leads to cartilage and bone destruction by osteoclast activation. This osteoclast activation leads to typical RA symptoms and is the therapeutic target. Several kinds of drugs are used...